Moreover, frequent use of salbutamol is an indication of poor asthma control and an increased use of controller therapy should be considered. An heterogenous response to beta agonist therapy has been described and individual response is related to many factors, including: the relative contribution of bronchoconstriction versus airway inflammation and edema in producing the airway obstruction, different triggering mechanisms, the duration of symptoms, the patient's age and the route of medication delivery.
Salbutamol is normally delivered through the inhaled route while intravenous salbutamol is used when children are unresponsive to inhaled treatment [A]. Less common are the oral and subcutaneous routes. Inhaled SABAs, administered through a MDI with attached spacer device along with infant- or child-sized mask or by nebulization, have the advantages of smaller doses and fewer side effects [ 3 ].
Inhaled SABAs allow selectivity for beta-2 receptors on bronchial smooth muscle to achieve bronchodilation without significant tachycardia associated with activation of beta-1 receptors on cardiac muscle. The incidence of adverse effects is dependent upon age of patient, dose, and route of administration. Examples of possible mild or moderate side effects in children and adolescents, not very common at recommended doses, include: palpitations, tachycardia, excitement, hyperactivity, insomnia, nervousness, shakiness and unpleasant taste inhalation site [ 4 ].
National Center for Biotechnology Information , U. Journal List Ital J Pediatr v. Ital J Pediatr. Published online Sep See all videos. How to use a Standard MDI puffer. Print page Using your inhaler puffer properly is important when you have asthma or COPD chronic obstructive pulmonary disease. Medications A standard puffer is used with many different medications. Other inhaler types See our complete How-to video library for other inhaler types and how to use them.
Acknowledgement Thanks to Ms Judi Wicking, asthma and respiratory educator, and the patient who participated in this film clip. Disclaimer Although all care has been taken, this video is a general guide only, which is not a substitute for assessment of appropriate courses of treatment on a case-by-case basis. Metabolic change ; myocardial ischaemia. If fluid-restricted, can be given undiluted through central venous catheter [unlicensed].
For nebulisation , dilute nebuliser solution with a suitable volume of sterile Sodium Chloride 0. With intravenous use in adults. When used for Asthma. For choice of therapy, see Asthma, acute and Asthma, chronic. For inhalation by nebuliser , the dose given by nebuliser is substantially higher than that given by inhaler. Patients should therefore be warned that it is dangerous to exceed the prescribed dose and they should seek medical advice if they fail to respond to the usual dose of the respirator solution.
Tablet , Oral solution , Solution for injection , Solution for infusion , Pressurised inhalation , Inhalation powder , Nebuliser liquid. Other drugs classified as selective beta2-agonists short-acting. By inhalation of nebulised solution For Adult 2. By inhalation of nebulised solution For Child 1 month—4 years 2. For Child 5—11 years 2.
At recommended inhaled doses, the duration of action of salbutamol is about 3 to 5 hours.
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